During the infection of Enterotoxigenic Escherichia coli (ETEC), forkhead box O6 (FOXO6) interacts with the m6A methylase METTL3 to promote the transcription of GPR161 (encoding G protein-coupled receptor 161), which in turn regulates the expression of intestinal β-defensin [29]. The gene discussed is FOXO6; the disease is infection.