SNCA and neurodegenerative disease: Inhibition of the autophagy–lysosome pathway is the proposed mechanism by which α-synucleins contribute to the pathogenesis of LB-associated neurodegenerative diseases with an accumulation of α-synuclein fibrils resulting in the failure to remove insoluble aggregates due to dysfunctional autophagy, increased oxidative stress, and mitochondrial dysfunction [4,36,38].