MAPT and Alzheimer disease: In the study by Liu et al. [86] with several pools of Tau proteins isolated from an AD brain, it was observed that Tau is abnormally hyperphosphorylated and glycosylated when there is an imbalance between phosphorylation and dephosphorylation, favoring the formation of intraneuronal neurofibrillary tangles (NFTs) which is one of the histopathology’s characteristics of AD.