Materials and methods: To perform a cohomprensive epitope mapping of anti-HCV antibodies, we analized 71 plasma samples of positive subjects, including 49 HCC patients, nine cryoglobulinaemic patients, and 13 asymptomatic HCV chronic infected subjects on a peptide microarray platform made of 5952 overlapping 15-mer synthetic peptides covering the whole HCV proteome (C, E1, E2, NS2, NS3, NS4A, NS4B, NS5A, NS5B and P7). Here, KRAS is linked to hepatocellular carcinoma.