Materials and methods: We investigated differences in prothrombin time (PT) and international normalized ratio (INR) as well as in Fibrinogen and D-dimer levels between unvaccinated COVID-19 patients who had been transferred to an ICU within two weeks after admission (n = 82) and COVID-19 patients with stable course of the disease (n = 74). The gene discussed is F2; the disease is COVID-19.