We did not have CSF samples from the healthy control group to compare with, and no reference to illustrate if the levels are high or low other than a study measuring S100A8/A9 in the CSF at concentrations around 100 pg/ml in healthy controls and 250 pg/ml in AD patients [19], which was lower than the median concentrations in this study. The gene discussed is S100A8; the disease is Alzheimer disease.