GBP1 and Herpesviridae infectious disease: According to our results, deletion of the ΔCAAX motif of GBP1 still possessed anti-PRRSV effects (Figure 4), which was not consistent with a previous report that the ΔCAAX motif is not sufficient for antiviral effects during Kaposi’s sarcoma-associated herpesvirus infection [53], implying that for different pathogens, the molecular mechanisms by which GBP1 exerts its biological functions differ.