CD4 and disease arising from reactivation of latent virus: To examine the innate immune landscape in latent cells we utilized multiple cell line models of HIV latent infection, including two different Jurkat CD4 + T cell latency models, JLat9.2 and JLat11.1, and the CEM CD4 + T cell ACH2 latency model, each harboring silent HIV provirus [38–40].