In particular plasma samples of HCV positive subjects, including HCC patients and cryoglobulinaemic patients as well as asymptomatic HCV chronic infected subjects have been analyzed on a peptide microarray platform made of 5952 overlapping 15-mer synthetic peptides covering the whole HCV proteome (C, E1, E2, NS2, NS3, NS4A, NS4B, NS5A, NS5B and P7). This evidence concerns the gene KRAS and hepatocellular carcinoma.