IL1B and familial Mediterranean fever: The biological explanation for the effect of stress on FMF attacks may be related to activation of the sympathetic system, initiating the release of catecholamines (epinephrine and norepinephrine), which leads to the secretion of Il-1β, activation of the inflammasome via activation of cAMP signaling pathway protein kinase A (PKA), and an increase in gene expression of REDD1 (regulated in development and DNA damage responses) [7].