As an example, latency-associated protein (LAP) is covalently bound to latent TGF-β binding protein (LTBP), and MMP-2 and -9 is able to release latent LAP/LTBP complex resulting in increases of the active form of TGF-β1, thereby promoting lung fibrosis progression [10, 11]. This evidence concerns the gene TGFB1 and pulmonary fibrosis.