Moreover, the upregulation of TNFRSF1B, TNFRSF8, TNFRSF9, and TNFRSF10 expression, as well as elevated levels of TNF, suggested apoptotic signal transition through the TNF family membrane receptors, which was also detected in tumour cells treated with chemotherapeutic drugs [32, 33]. This evidence concerns the gene TNFRSF8 and neoplasm.