RAPGEF1 and infection: While C3G (Fig. 3A), Asta (Fig. 3B), D3R, and C3R (data not shown), did not influence HSV-1 infection, D3G inhibited infection by two orders of magnitude (significance p = 6.7*10–8) at a concentration of 150 μg/ml, indicating that D3G is an active compound in the extract (Fig. 3A).