Hypoxia increased the invasiveness of fibroblast cells, whereas inhibition of HDAC3 using siRNA caused decreases of 46.7–72.2% and 32.9–56.1% in hypoxia-induced invasion in DHLF-IPF and MRC-5 cells, respectively (Fig. 2c and Supplementary Fig. 2c). This evidence concerns the gene HDAC3 and idiopathic pulmonary fibrosis.