HDAC3 and fibrosis: In addition, the expression levels of HDAC3, CAIX, and Snail were increased by 105-228%, 89-173%, and 41-828%, respectively, in lung tissues from mice with bleomycin-induced fibrosis, whereas mice with additional injection of HDAC3 siRNA showed decreases of 32-90%, 53-98%, and 39-100% in the expression levels of HDAC3, CAIX, and Snail, respectively.