GFI1B and acute myeloid leukemia: Therefore, we hypothesize that in leukemic cells, the effect of some mutations on metabolic regulation is less potent than that of Gfi1b, and others are robust enough to mitigate the metabolic effect of Gfi1b loss; thus, the divergent effect of Gfi1b on metabolic phenotypes in AML cells reflect the effects of different mutations (Fig. 4i).