In line with in vivo data, Gfi1b-KO leukemic cells had a higher level of mitochondrial respiration than Gfi1b-WT, but notable metabolic heterogeneity was observed in the single colonies of Gfi1b-KO and Gfi1b-WT AML groups (Supplementary Fig. S8d). The gene discussed is GFI1B; the disease is acute myeloid leukemia.