Except for AML/ETO preleukemic cells, murine Gfi1b-KO HPCs, MLL/AF9, and BCR/ABL preleukemic cells, and MLL/AF9 AML cells were more sensitive to metformin treatment than Gfi1b-WT cells (Fig. 6a, b and Supplementary Fig. S10a, b). The gene discussed is KMT2A; the disease is acute myeloid leukemia.