KRT18 and neoplasm: As only the tissues with positive CK18 detected and within the gland with positive HMCK detected are determined as cancerous tissues, in order to identify cancerous tissues and determine the tumor stage and grade, medical doctors have to manually align three gigabyte-size microscopic WSIs of each patient and then subjectively quantify cancerous tissues of WSIs, to perform simultaneous analysis of an IHC HMCK slide, an IHC CK18 slide and a H&E slide.