To test our hypothesis that GGPP is the functional metabolite downstream of PCSK9 in KRAS-mutant CRC, we silenced geranylgeranyl pyrophosphate synthase (GGPS1), which catalyzes the biosynthesis of GGPP, in PCSK9-overexpressing DLD1 cells. Here, GGPS1 is linked to colorectal carcinoma.