PRMT5 and neuroblastoma: We explored the consequences of PRMT5 inhibition on global signaling networks in neuroblastoma cells treated with DMSO or GSK591 by a proteomics-based targeted screen, an assay that is a similar approach to proximity ligation assay in a high throughput manner to measure the expression, modification, and cleavage of crucial proteins involved in 20 signal transduction pathways (https://www.activsignal.com/).