TGFB1 and Cirrhosis: Pathway analyses using the tool PROGENy34,35 identified fibro-inflammatory pathways TGFβ, NFκB, TNFα, and hypoxia and pathways associated with liver damage-repair, regeneration and malignant transformation such as EGFR, MAPK, P53, PI3K, and WNT to be significantly upregulated in cirrhosis patients compared to controls (Fig. 6c, Supplementary Table 3).