MKI67 and Hepatic fibrosis: 13-week-old NEMO∆hepa/Nlrp6−/− mice displayed increased leukocyte infiltration, aggravated liver fibrosis evidenced by SR staining and increased hepatocyte proliferation supported by immunohistochemistry (IHC) staining for Ki67 (Fig. 3a, b, Supplementary Fig. 3a).