TLR4 and neoplasm: While mRNA expression of the pro-inflammatory cytokines Tnfa, Il6, Il1β as well as inflammasome components Caspase-1 and Nlrp3 remained unchanged in tumor tissue (Supplementary Fig. 1d), infiltration of myeloid CD11b+ was linked to higher gene expression levels of the pro-inflammatory genes Tnfa, Tlr4, Il1β, Nlrp3 and Ccl5 in whole liver tissue without macroscopic tumors (Fig. 1g, Supplementary Fig. 1e).