However, p53 is mutated in more than 50% of all human cancers205 and is functionally inactivated by mutational, viral, or cellular patterns in most types of cancer.206 A large proportion of mutant p53 species are highly overexpressed in cancer cells, and some p53 mutations exert negative dominance effects through coaggregation, hetero-oligomerization, and prion-like aggregation with mutant or normal p53 protein. Here, TP53 is linked to cancer.