Among these suppressors, p53 appears to be extremely crucial because it responds to multiple stress signals by coordinating distinct cellular activities, such as permanent and impermanent cell cycle arrest, apoptosis and cell senescence, which are all correlated with tumor suppression.199–203 p53 is a cellular stress sensor that suppresses tumorigenesis via transcriptional activation,204 and 53BP1 helps to stabilize and enhance p53 gene expression.199. The gene discussed is TP53; the disease is neoplasm.