Another example is Nucleophosmin (Npm1), a highly abundant protein that contributes to the maintenance of genome stability and regulation of the p53 tumor suppressor pathway and has been implicated in mediating the LLPS of nucleolar granule components.41–43 The Npm1 monomer encodes only a 2-valent interaction partner, which is insufficient for triggering phase separation. This evidence concerns the gene NPM1 and neoplasm.