The Mst1/2 (two Hpo homologs) kinases are significant components of the Hippo pathway in regulating immune systems and cell proliferation via a tumor suppression mechanism.234 However, the membraneless Laforin-Mst1/2 complex robustly sequesters the Hippo kinases Mst1/2 and abolishes their repression of oncogenic YAP signaling. The gene discussed is MST1; the disease is neoplasm.