DNAJB1 and fibrolamellar hepatocellular carcinoma: The DnaJB1-PKAcat fusion oncogene has been detected in nearly all fibrolamellar carcinoma patients, and the inhibition of RIα LLPS results in disruption of cAMP compartmentation and deregulation of the cAMP/PKA signaling pathway, which consequently leads to tumorigenesis.112 Therefore, the above-described example illustrates the importance of normal phase separation to the organism and the pathogenic potentiality of molecular chaperones in the regulation of LLPS.