RSPO2 and neoplasm: In agreement with previous results from bulk transcriptomics30, numerous genes coding for components of the WNT signaling pathway were upregulated in the non-mesenchymal tumor cell populations, including LGR5, LGR6, FZD3, RSPO2, WNT5A, WNT3, and DAAM2 (Fig. 1b, c and Supplementary Data 2).