Notably, treatment with DDP or ADM 12 h before the addition of Ara-C had stronger synergistic effects in AML cells than simultaneous addition of the two chemical agents (Fig. 6C, D), indicating that this synergism is dependent on the downregulation of NONO/SAMHD1 before Ara-C treatment. The gene discussed is SAMHD1; the disease is acute myeloid leukemia.