Indeed, a recent study indicated that SIRT5is overexpressed in NSCLC cells, which is associated with poor prognosis.Consistent with this, SIRT5 downregulation suppressed tumor cell growthand differentiation121 and sensitized lungcancer cells to genotoxic drugs such as cisplatin, 5-fluorouracil,and bleomycin both in vitro and in vivo. The gene discussed is SIRT5; the disease is neoplasm.