GLS and neoplasm: Since it was reported that ammoniacould induce autophagy and mitophagy in tumor cells, the SIRT5-mediatedinhibition of GLS could overcome this protective mechanism for tumorcells, suggesting a tumor suppressor role for SIRT5 in this context.84 Conversely, another study suggested that SIRT5-mediateddesuccinylation at Lys164 protects GLS from ubiquitination at Lys164and the consequent proteasomal degradation, thereby stabilizing itand supporting glutamine catabolism.85