In gastric cancer, SIRT5 overexpression inhibitsoxoglutarate dehydrogenase(OGDH), thus decreasing ATP production, increasing ROS levels, andleading to the inhibition of cancer cell proliferation and migration.128 Furthermore, enhanced SIRT5 activity leadsto cell cycle arrest at the G1/S phase in tumor cells due to the negativemodulation of cyclin-dependent kinase 2 (CDK2) and the inhibitionof glycolysis (Figure 4).129. The gene discussed is SIRT5; the disease is cancer.