Liang et al. reported that SIRT5 was overexpressed in culturedSH-EP neuroblastoma cells, where it counteracted oxidative stressby reducing ROS levels and preventing apoptosis (Figure 4), thus exerting a tumor-promotingfunction.136 SIRT5 is also overexpressedin ovarian cancer,137 where it protectstumor cells from genotoxic drugs such as cisplatin by modulating theNRF2/HO-1 pathway, which in turn increases the cellular levels ofthe ROS scavenger GSH (Figure 4).138. This evidence concerns the gene SIRT5 and ovarian cancer.