SIRT5 and cancer: These mechanisms play a defensive role against chemotherapyor stress mechanisms such as hypoxia or fasting.84 Importantly, in cancer cells, glutamine catabolism is necessaryfor ATP production and lipid biosynthesis to support cell proliferation.Indeed, glutamine is crucial for the anaplerotic replenishment ofthe TCA cycle through its catabolic product α-ketoglutarate.131 Hence, in these cases, SIRT5 acts as a tumorsuppressor, rendering tumor cells more susceptible to chemotherapeuticsand environmental stresses and causing a decrease in ATP production.