SIRT5 negativelyregulates the expression of SAD1/UNC84 domain protein 2 (SUN2) (Figure 4), an important componentof the linker of the nucleoskeleton and cytoskeleton (LINC) complex.121 SUN2 inhibits the Warburg effect, a metabolicalteration in which ATP is produced mainly from glycolysis ratherthan oxidative phosphorylation, thereby generating immediate energyto support cancer cell proliferation.133 SUN2 activity facilitates the suppression of cancer cell growth,metastasis, and the increased susceptibility to apoptosis inducedby cisplatin. This evidence concerns the gene SIRT5 and cancer.