A recent report suggested that SIRT5is pivotal in facilitating the replication of severe acute respiratorysyndrome coronavirus 2 (SARS-CoV-2), the etiologic agent causing thecurrent COVID-19 pandemic.86 It is thereforeapparent that SIRT5 has a rather pleiotropic nature, which is typicalof other epigenetic proteins. The gene discussed is SIRT5; the disease is COVID-19.