Yang et al. showedthat SIRT5-mediated desuccinylation at Lys280activates the catabolizing enzyme serine hydroxymethyltransferase2 (SHMT2), which in turn promotes tumor progression in osteosarcomaU2OS and colorectal carcinoma (CRC) HCT116 cells (Figure 4).139 Indeed, SIRT5 KO or the expression of the succinylation mimeticSHMT2 mutant (K280E) resulted in the suppression of tumor growth both in vitro and in vivo. Here, SHMT2 is linked to colorectal carcinoma.