SIRT5 and acute myeloid leukemia: Moreover, 2c-et was also effective in both genetically engineered and xenograftmouse models of AML,135 while 3b-et was effective when administeredto ex vivo AML cells subsequently injected in mice.147 Notably, compounds 3b-et, 3d-et, and 3i-he showed cellulareffects only in SIRT5-dependent AML cell lines, thereby indicatinga connection between SIRT5 inhibition and the observed anticancereffects.