SIRT5 and neoplasm: SIRT5 catalyzes NAD+-dependent deglutarylation, desuccinylation, and demalonylationof metabolic enzymes implicated in glycolysis;59 mitochondrial oxidative phosphorylation;55 fatty acid β-oxidation (FAO);57,58 ROS response;56 glutamine metabolism;and ammonia detoxification.53,84,85 In addition, SIRT5 expression is altered in a variety of cancertypes, and it may behave as either a tumor promoter or a tumor suppressor.SIRT5 also plays significant roles in cardiac health maintenance andthe neuronal stress response.