Consistent with this, SIRT5KO or treatment with the nonselective SIRT5 inhibitor GW5074 (seecompound 11 in section 4.1)augmented LDHB acetylation at Lys329 and inhibited LDHB activity,which reduced autophagy and CRC cell growth both in vitro and in vivo. The gene discussed is LDHB; the disease is colorectal carcinoma.