PTPN11 and prostate adenocarcinoma: In PRAD, we found PTPN11 was remarkably positively related to several immunomodulators, including immunostimulator IL6R expression (spearman correlation of 0.425), immunoinhibitor TGFBR1 expression (spearman correlation of 0.415), and CXCL12 expression (spearman correlation of 0.18) (Figure 9G–9I), which indicated PTPN11 might regulate the immunomodulators IL6R, TGFBR1, and CXCL12 in PRAD.