PTPN11 and invasive breast carcinoma: However, expression of PTPN11 was found to be relatively lesser in breast invasive carcinoma (BRCA), glioblastoma multiforme (GBM), kidney renal clear cell carcinoma (KIRC), LUAD, prostate adenocarcinoma (PRAD), thyroid carcinoma (THCA), and uterine corpus endometrial carcinoma (UCEC) compared to that of relating healthy tissues (Figure 1A).