However, other proteins such as albumin and immunoglobulins have higher molecular weight than α1-MG, and can not pass through glomeruli in normal conditions, thus, α1-MG is much easier to excrete in urine even with renal tubules failures but without glomeruli failures, which is probably the important causes why urinary α1-MG especially α1-MG/CR is a more powerful predictor for general DKD than other urinary proteins. The gene discussed is ALB; the disease is diabetic kidney disease.