IRS1 and melanoma: Of all these genes, 10 genes (CAV1, IRS1, LMNA, LMNB2, PEA15, POLD1, PRKAG2, RNASEH2A, SLC29A1, and SLC2A1) were all downregulated, while 7 genes were all upregulated (AMACR, ARNT2, BBS2, FOS, FOXO1, PCSK1, and PLAG1) in suspended melanoma cells, as listed in Table 2.