Despite low basal levels of FHL2 expression in the pancreas, previous finding by Bacos et al, showing that knockdown of FHL2 in INS-1e rat insulinoma cells decreases glucose-stimulated insulin secretion (GSIS), inspired us to study the role of FHL2 in glucose metabolism in more detail in human datasets of individuals with type 2 diabetes, in FHL2-deficient mice and in MIN6 cells. The gene discussed is INS; the disease is type 2 diabetes mellitus.