The second model utilizes a myeloblast-like cell line 32D cells from C3H/HeJ mice transduced with FMS-like tyrosine kinase 3 (FLT3) with internal tandem duplications (FLT3ITD), a constitutively active receptor tyrosine kinase found in 25–30% of AML patients [24]. Here, NTRK1 is linked to acute myeloid leukemia.