FUS and amyotrophic lateral sclerosis: For example, in ALS (amyotrophic lateral sclerosis) mutations, the FUS protein phase separates into abnormal neuronal granules, and ectopic aggregates of FMRpolyG protein in ovarian stromal cells are associated with Fragile-X-associated primary ovarian insufficiency (Ganion 1991; Buijsen et al. 2016; Friedman-Gohas et al. 2020).