PRKDC and neoplasm: Higher TMB was related to better OS and better outcomes from immune checkpoint inhibitor (ICI) therapy in tumor patients.[27] Radar plots (Fig. 6B) showed a positive association between PRKDC and TMB in KICH (P = .0027) and LUAD (P = 1.1e-05), but a negative association in THCA (P = .008) and COAD (P = .021).