Studies in rectal cancer cells have found that excessive ROS can prompt the Thx-like domain of NHLRC2 to interact with caspase-8 zymogen, allowing NHLRC2 to be cleaved and degraded at Asp580, ultimately leading to apoptosis.[21] Therefore, the simultaneous deficiency of the above 2 genes can lead to a complete dysregulation of ROS homeostasis in the patient, and whether there is a correlation between NDUFS6 and NHLRC2 protein function remains to be solved. Here, CASP8 is linked to rectal cancer.