High expression of NHLRC2 mRNA can be detected early in both human and mouse brain development,[15] while abnormal changes in NHLRC2 proteins and NHLRC2 mRNA levels can be detected in patients with such neurodegenerative diseases as Parkinson disease and Alzheimer disease.[16,17] Animal studies have confirmed that a homozygous mutation (p.Val311Ala) in the β-propeller domain of NHLRC2 can lead to a range of neural tube-related developmental malformations.[18] In addition, NHLRC2 may be widely involved in embryonic development. This evidence concerns the gene NHLRC2 and early-onset autosomal dominant Alzheimer disease.