Mice studies have founded that NHLRC2 knockout can lead to increased hnRNP C2 expression in neurons and hippocampal pyramidal cells, accumulated RNA-binding proteins, and dysregulated RNA metabolism, ultimately causing neurodegenerative symptoms in FINCA syndrome.[32] Two mutations c.1749C> G (p.F583L) and c.2129C> T (p.T710M) carried by the patient in this study were located in the C-terminal β-strand domain and may also be one of the reasons why neurodegenerative symptoms were not apparent in this patient. Here, NHLRC2 is linked to fibrosis, neurodegeneration, and cerebral angiomatosis.