ET-1 mediates the activation of the G protein-coupled receptor endothelin A (ETA) in VSMCs, leading to endothelial dysfunction, inflammation, atherosclerosis, and vascular proliferation.[73] A study by Liang showed that the EDN1 tag SNP rs6458155 was associated with CAD risk in the Chinese Han population, possibly due to an increase in circulating ET-1 level.[74]. This evidence concerns the gene EDN1 and endothelial dysfunction.