Presepsin is a soluble CD14 protein that modulates the immune response by interacting with T and B cells.[15] The presepsin level is used for early diagnosis and prognostic assessment of patients with systemic infections.[15] Especially in sepsis patients, the serum levels of presepsin are elevated before those of procalcitonin or IL-6; presepsin serves as a biomarker of sepsis.[16,17] Carpio et al[18] set presepsin thresholds for early risk stratification of sepsis patients: <200, very low risk; >300, moderate risk; >500, high risk; and > 1000 ng/L, very high risk. Here, CD14 is linked to Sepsis.