Remarkably, the expression of ACE-2 in testes is age related.[31] The highest expression of ACE-2 was reported in 30-year-old patients, which is higher than those in their twenties, while 60-year-old patients showed the lowest level of expression of ACE-2.[14] This may suggest that young male patients are at higher risk of testicular dysfunction by COVID-19 infection than older male patients. The gene discussed is ACE2; the disease is testicular disorder.