TLR2 and TLR8-AS1 expression was increased in the majority of tumours, although TLR2 expression was decreased in LUSC (P0.001), LUAD (P0.001), PRAD (P0.001), BRCA (P0.001), and LIHC (P0.001), and TLR8-AS1 expression was specifically decreased in LUSC (P0.001) and PRAD (P0.001). This evidence concerns the gene TLR8 and prostate adenocarcinoma.