In cases with history of previous infection, anti‐S1 IgG response with Moderna vaccine has been significantly more intense, with a mean value of 21,881 AU ml−1 (95% CI: 19,655 to 24,109) versus 15,733 AU ml−1 with Pfizer (95% CI: 13,951 to 17,515). This evidence concerns the gene PSMD1 and infection.