KEAP1 and acute respiratory distress syndrome: Hu et al. [28] demonstrate that the Nrf2-Keap1-antioxidant response element (ARE) signaling pathway can eliminate oxidative stress and its associated inflammation to improve traumatic lung injury-related pathology, and a Keap1-Nrf2 inhibitor designed by Zhang et al. is expected to be a novel protective agent of ALI [29].