In turn, M3 is associated with virtually all other strong predictors: larger tumour size (Shields et al., 2007), BAP1 mutation (Harbour et al., 2010), gene expression class 2 (Onken et al., 2004; Worley et al., 2007), vasculogenic mimicry patterns (Meir et al., 2007), extraocular extension (van Beek et al., 2014) and tumour cell morphology (Scholes et al., 2003; Sisley et al., 1997). The gene discussed is BAP1; the disease is neoplasm.