Scientists believed that drugs such as ibuprofen could exacerbate the COVID-19 disease by upregulating the angiotensin-converting enzyme 2 (ACE2), which serves as an entry receptor for SARS-CoV-2.33 On March 18, 2020, the WHO advised patients experiencing COVID-19 symptoms to avoid the use of ibuprofen and other NSAIDS due to the same reasons. This evidence concerns the gene ACE2 and COVID-19.