IFNA1 and atherosclerosis: The co-inflammatory role of type-I IFNs in T-cells in association with atherosclerosis is less described, however, it has been shown that pDCs colocalise with and stimulate T-cells in atherosclerotic plaques through IFNα, enabling cytotoxic T-cells to kill vascular smooth muscle cells, which can destabilize the plaque (66).