Robinson et al. showed that CD8+ T-cells from high cardiometabolic risk JSLE patients had enriched activation, pro-apoptotic and SLE-specific IFN-signaling transcriptomic pathways associated with atherosclerosis, highlighted by a significant pathway enrichment overlap with transcriptomes of CD8+ T-cells isolated from human and mouse atherosclerotic plaques (54, 59). The gene discussed is CD8A; the disease is systemic lupus erythematosus.