Despite this, effector memory CD8+ T-cells in adult-onset SLE have been shown to have increased apoptotic profiles (increased tendency to undergo apoptosis upon stimulation) and decreased proliferative capacity, but also to express high levels of IFN-γ, perforin and granzyme B, highlighting possible pathogenic mechanisms of chronic inflammation and organ damage (33). The gene discussed is CD8A; the disease is systemic lupus erythematosus.