These findings suggested that SLC12A3 polymorphisms were associated with more significant glomerular hyperfiltration in the earlier stage of hypertension (cohorts 1 and 2), and resulted in a more rapid decline in eGFR in the later stage of hypertension (cohort 3) (Supplementary Figures 1, 2). The gene discussed is SLC12A3; the disease is hypertensive disorder.