A recent meta-analysis compared the association between cardiovascular events and FGF23 in the general population, non-dialysis patients with CKD, and dialysis patients, although serum FGF23 went up with the progression of CKD, there was no powerful evidence that increased FGF23 contribution to heart failure, stroke, or myocardial infarction either in the overall or any of the three separate groups (29). The gene discussed is FGF23; the disease is heart failure.