In a mouse model of Alzheimer’s disease (AD), it was shown that IHT can improve learning and memory deficits, slow Aβ accumulation in the cerebral cortex and hippocampus and increase there the levels of such neuroprotective trophic factors as erythropoietin and brain-derived neurotrophic factor (BDNF) (Ryou et al., 2021). Here, BDNF is linked to early-onset autosomal dominant Alzheimer disease.