TARDBP and amyotrophic lateral sclerosis: In ALS/FTLD, cytoplasmic TDP-43 aggregates occur predominantly within the affected neurons, but they can also occur in oligodendroglial cells (Amador-Ortiz et al., 2007; Higashi et al., 2007; Nakashima-Yasuda et al., 2007; Neumann et al., 2007; Nishihira et al., 2008; Zhang et al., 2008; Yamanaka and Komine, 2018).