TARDBP and amyotrophic lateral sclerosis: To determine the pathological relevance of TDP43C-spl and sTDP-43 variants to ALS, we generated an antibody to a synthetic peptide corresponding to the C-terminal 18 aa sequence present in TDP43C-spl and the putative proteins encoded by TDP-43 transcripts−2,−4, and−7 (Figure 1B).