N-terminally truncated forms of TDP-43 have been associated with ALS/FTLD, this includes TDP-25 and TDP-35 which may be generated through proteolytic cleavage and/or through abnormal RNA processing events (Dormann et al., 2009; Herskowitz et al., 2012; Yamashita et al., 2012; Xiao et al., 2015). Here, TARDBP is linked to amyotrophic lateral sclerosis.