Wang et al. (2010) found that the concentration of NEP is negatively related to Aβ accumulation in d patients with no cognitive impairment (NCI) or mild cognitive impairment (MCI), while the relationship disappears among AD patients. Yamamoto et al. (2017) studies the relationship between the secretion of NEP and Aβ degradation in cultured astrocytes and found epigallocatechin gallate (EGCG) will promote the secretion of NEP and induce the degradation of Aβ, probably via extracellular signal-regulated kinase (ERK) or phosphoinositide 3-kinase (PI3K) -mediated pathway. This evidence concerns the gene MME and Alzheimer disease.