Rodent PD models show either increased (Filichia et al., 2016; Zhang et al., 2020) or decreased mitochondrial DRP1 localization and fission (Portz and Lee, 2021), depending on whether the model was generated using toxins such as rotenone/MPTP or by overexpression of a SNCA mutant, respectively, and this suggests that the localization of DRP1 is altered in conditions of acute versus chronic stress. Here, SNCA is linked to Parkinson disease.