Alzheimer's disease (AD) is the most common neurodegenerative pathology and is defined by the co-occurrence of extracellular accumulation of β-amyloid (Aβ) peptides in amyloid plaques and intraneuronal deposition of hyperphosphorylated tau in neurofibrillary tangles (Alzheimer, 1906). This evidence concerns the gene MAPT and Alzheimer disease.