ATP13A2 and Parkinson disease: Loss-of-function (LOF) mutations in the P5B-type ATPase and lysosomal polyamine exporter ATP13A2 (PARK9) are causative for a plethora of NDs, including PD (van Veen et al., 2014), and result in lysosomal polyamine accumulation and subsequent rupture (van Veen et al., 2020).