ACTN3 and cancer: Overrepresented pathways involved ten genes: Cflar, Fos, Actn3, Ar, Cacna1s, Col1a1, Col3a1, Col5a2, Il15, and Tnnc1. Among these genes, all, except Actn3 and Tnnc3, were relevant in signaling pathways related to cancer and the immune system, such as the nuclear factor-kappa B, tumor necrosis factor, mitogen-activated protein kinase (MAPK), Toll-like receptor, B- and T-cell receptor signaling, and PI3K-AKT signaling pathways (Supplementary Data S1).