Among them, we confirmed that 11 genes from the skeletal muscle (Col3a1, Col5a2, Tnnc1, Col1a1, Osr2, Ifrd1, Trim63, Asb2, Maff, Myl6b, and Fos), five from the lungs (Cflar, Actn3, Myoz2, Il15, and Acta1), and two from the heart (Myoc, and Trim63) showed reverse expression changes between high-intensity aerobic exercise and cancer-bearing. This evidence concerns the gene ACTN3 and cancer.