Li et al. (2017) found that CIMT promoted neurogenesis and angiogenesis by increasing the expression of endogenous hypoxia-inducible factor-1α and vascular endothelial growth factor and ultimately induced neuroprotection and functional recovery after cerebral ischemia. Zhai and Feng (2019) have demonstrated that compared with fasudil, CIMT resulted in better angiogenesis, nerve regeneration and nerve function recovery at 4 weeks after cerebral ischemia/reperfusion. Here, VEGFA is linked to Cerebral ischemia.