For example, in Alzheimer’s disease, T217-phosphorylation exacerbates wild-type tau hyperphosphorylation with aggravated tau cleavage/fibrillization and cognitive impairments (Wang et al., 2021); in mouse, altering KCC2 phosphorylation resulted in long-term abnormalities in social behavior and memory retention (Moore et al., 2019). Here, MAPT is linked to early-onset autosomal dominant Alzheimer disease.