CD8A and neoplasm: The higher the proportion of immune score in the tumor microenvironment, the better prognosis in most patients (Na and Choi, 2018).In addition, tumor-infiltrating lymphocytes (TLSs), including CD4 and CD8 T cells, have been linked to increased survival rates (Vassilakopoulou et al., 2016; Zeng et al., 2019).