Among cancer patients, who had or had not been previously exposed to known cardiotoxic agents, (i) those who survived after chemotherapy agents without acute cardiotoxicity (as defined by Children’s Oncology Group guidelines) also exhibited increased cardiac dysfunction, body mass index, fasting serum non-high-density lipoprotein cholesterol, insulin, and C-reactive protein compared to non-cancer siblings; (ii) those who survived after chemotherapy agents with acute cardiotoxicity exhibited similar phenotypes as described in (i). This evidence concerns the gene INS and cancer.